Organizers: Alexa Burger (CU Anschutz) & Evgeny Kvon (UC Irvine)
The satellite symposium will occur prior to the opening of the Society for Developmental Biology 82nd Annual Meeting organized by the Society for Developmental Biology (SDB)
Symposium Overview
The symposium aims to connect developmental biologists who are interested in gene regulation by transcriptional enhancers and its role in development, evolution, and congenital disorders. It will be a platform where junior scientists, including graduate students and postdocs, can network and interact with rising leaders in the field. It will foster new collaborations and exciting idea exchanges between SDB meeting attendees.
The program will focus on transcriptional enhancers, abundant non-coding DNA elements regulating gene expression during development and in response to intrinsic and external signals. It will feature four sessions:
1. Mechanism of enhancer function in development
2. Enhancer in evolution
3. Enhancer grammar and regulatory code
4. Enhancers in human biology and disease
Each session will include talks from invited speakers and selected talks chosen from abstracts of early career researchers and trainees, as well as trainee lightning talks.
Meeting hashtag: #2023SDBEnh
Deadlines
Abstract submission – April 10
Registration – June 20
Housing reservation at Hyatt Regency – June 28.
Venue and Housing
The symposium will be held in person on July 20, 2023, 8:30 AM - 4:00 PM at the Hyatt Regency in Chicago, IL.
Registration
Select the symposium at no additional cost when registering for the main conference. For those who can only attend the satellite symposium, there is a Satellite Symposium-Only registration form ($150 for Faculty/Staff/Emeriti and $120 for Students and Postdocs). Please note that there will not be onsite registration for the symposium.
Abstract submission
Submit your abstract through a submission form (separate from the main SDB meeting) to be considered for a short talk. For consideration for a short talk, preference will be given to those who have registered. Abstract submission is open to all career stages, but preference will be given to trainees and early career scientists. There will be no poster session.
Speakers
Luisa Cochella
Assistant Professor
John Hopkins University
Yana Kamberov
Assistant Professor
University of Pennsylvania
Emma Farley
Assistant Professor
UC San Diego
Mustafa Mir
Assistant Professor
University of Pennsylvania
Emily Hodges
Assistant Professor
Vanderbilt University
Alex Nord
Associate Professor
UC Davis
Alexa Burger
Associate Professor
CU Anschutz
Evgeny Kvon
Assistant Professor
UC Irvine
Organizers
Symposium Program (preliminary) – Thursday, July 20, 2023
8:30 – 8:40 AM Welcome by the Organizers
Mechanism of enhancer function in development (8:40 – 9:40 AM) – moderated by Evgeny Kvon
8:40 – 9:10 AM Luisa Cochella, Johns Hopkins University
Temporal integration of transcriptional inputs as a mechanism for cell diversification
9:10 – 9:40 AM Mustafa Mir, CHOP/University of Pennsylvania
Molecular kinetics of transcription regulation and nuclear organization during development
Lightning talks (9:40 – 10:10 AM) – moderated by Evgeny Kvon
9:40 - 9:46 AM Pashalis Kratsios, University of Chicago
Temporal modularity in transcription factor function controls neuronal cell type identity across different life stages
9:46 – 9:52 AM Brooke Jeffery, Michigan State University
Cis-regulatory Evolution in Enteric Nervous System Development
9:52– 9:58 AM Carly Sullivan, University of Calgary, Canada
Characterizing the Genetic Contribution of a Highly Conserved Enhancer of the Short Stature Homeobox 2 (Shox2) Gene in the Developing Mouse Limb and Hindbrain
9:58 – 10:04 AM Esra Erkut, University of Toronto, Canada
Conserved TBX20 cardiac enhancer activity is altered by CHD patient mutations
10:04 – 10:10 AM Jeremy Sandler, Stowers Medical Institute
A Gene Regulatory Landscape and Network That Drives Sensory Hair Cell Regeneration in Zebrafish
10:15 – 10:45 AM Break
Enhancers in Evolution (10:45 – 12:00 PM) – moderated by Alexa Burger
10:45 – 11:15 AM Yana Kamberov, University of Pennsylvania
Mind how you sweat! How enhancer divergence led to the accelerated evolution of the naked and sweaty ape
11:15 – 11:30 AM Cassie L. Kemmler, University of Colorado Anschutz Medical Campus
Conserved distant enhancers regulate notochord expression of vertebrate Brachyury
11:30 – 11:45 AM Aki Ushiki, University of California, San Francisco
Functional characterization of regulatory elements involved in bat wing development
11:45 - 12:00 PM Licia Selleri, University of California, San Francisco
“Why a Long Face?”: Identification of Craniofacial Enhancers Exhibiting Differential Activity in Mammals versus Avians
12:00 – 1:00 PM Lunch Break (on your own)
Enhancer Grammar and Regulatory Code (1:00 – 2:15 PM) – moderated by Cassie Kemmler
1:00 – 1:30 PM Emma Farley, University of California San Diego
Affinity-optimizing enhancer variants disrupt development
1:30 – 1:45 PM Robert Johnston, Johns Hopkins University
Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification in the fly eye
1:45 – 2:15 PM Alexander S. Nord, University of California Davis
More than open chromatin: the combinatorial transcription factor logic driving neurodevelopmental enhancer function
2:15 – 2:45 PM Break
Enhancers in human biology and disease (2:45 – 4:00 PM) – moderated by Grace Bower
2:45 – 3:15 PM Emily Hodges, Vanderbilt University
Understanding how DNA methylation mediates enhancer function to drive cellular phenotypes
3:15 – 3:30 PM Megan Leask, University of Otago, New Zealand
The regulatory landscape of metabolism in Polynesian populations
3:30 – 3:45 PM Han Liu, Cincinnati Children's Hospital
Modeling in Human Pluripotent Stem Cells and Mutant Mice Reveal Chromatin Domain Fusion and Enhancer- Promoter Rewiring as the Cause of SIX2-related Frontonasal Dysplasia
3:45 – 4:00 PM Robin Harris, Arizona State University
Manipulating damage-responsive enhancers to promote tissue regeneration
4:00 – 4:10 PM Concluding remarks
4:10 – 5:00 PM Break
5:00 PM Main SDB program start